Fools - Gold: redux
From the so-called National Autism Association:
Contrary to the statement on the National Autism Association's website, Dr. Hornig has not created a mouse model for autism. Not even close. So what is she "expanding"? She chronically overdosed autoimmune-disease-prone mice with mercury and didn't get autistic symptoms out of them, even though she was watching for what she assumed were the mousey version of autism symptoms.
She chronically overdosed her mice with thimerosal in a manner that does not mimic the vaccine exposure infants received during the 1990's in the U.S., and got almost no behavioral change out of them, but she did get what looks like peripheral neuropathy which she didn't report in the original paper. Since all this mercury didn't seem to affect the non-immune-sensitive mice at all, how dangerous can mercury be? She doesn't report if the other mice had peripheral nerve damage symptoms maybe all the mice she injected with mercury started to chew on their feet because of the peripheral nerve damage.
But now, she will put mercury in her mice again and then, later inject gold into them. Presumably, she will inject the gold, since that was the treatment Donald T got. But, maybe she'll mix up a "transdermal" gold-salt cream. The gold is supposed to act like a chelator, even though there's no biochemical reason to think that it would act that way in the human or mouse body.
Gold salts are used in some forms of juvenile arthritis. The way the treatment is carried out is to give injections once a week until the gold builds up in the body to a sufficient level.
This would tend to imply that the gold goes in and stays in wouldn't it? If it's going in and staying in, is it also carrying mercury out of the body with it? Has Hornig looked into how much of the gold will stay in the mouse? Has she looked into the damaging effects of gold?
Here is some information on the use of gold salts in Juvenile Rheumatoid Arthritis:
More on side effects of gold salts from a different source:

Abstract describing how gold from sodium aurothio[1,4-14C]malate (Radioactive Carbon 14 tagged gold salts, apparently) is deposited in a rat's body, " Gold was located principally in kidney, liver, lung and spleen with smaller amounts elsewhere" So did the gold not get past the blood-brain-barrier? If so, is that a problem if you are trying to chelate mercury out of a kid's brain?
MYOCHRYSINE®, injectible sodium aurothiomalate, is made by Rhône-Poulenc Rorer. One of the first questions Hornig needs to ask is, "Is this stuff I intend to use made by the utterly evil BIG pharma. And, "If so, should I really be buying the stuff and thereby promoting the continuation of evil? " Someone needs to ask these tough questions. Maybe the Institutional Review Board at Columbia University will. But then, they are probably supported in part by the utterly evil BIG pharma.
The idea that gold salts turned Donald T from an autistic person into a normal person is just bizarre, but it's typical of the cargo cult thinking of the never-ending Dan Olmsted and his followers.
Autism Diva
Au/relia
Liz Birt “Go for the Gold” Mouse Model, SafeMinds
Liz was a co-founder and board member of SafeMinds, a parent advocacy organization dedicated to expanding research on the role of mercury from vaccines and other sources as a cause of autism. One of the researchers which SafeMinds is funding is Dr. Mady Hornig of Columbia University’s Mailman School of Public Health.
Dr. Hornig has created a mouse model for autism using exposure to the mercury preservative thimerosal found in infant vaccines.
Expanding this research, she is developing a treatment protocol using gold salts which she will administer to these genetically susceptible mice to determine if the treatment might improve their behavior and brain function and if there are side effects.
Gold tightly binds mercury
and there are anecdotal reports of gold salts being effective in improving autism outcomes.
Gold salts (chrysotherapy) were also used for many years for the treatment of autoimmune diseases such as rheumatoid arthritis.
This project has been aptly named “Go for the Gold.” Dr. Hornig was inspired to undertake this research when she learned of Liz’s death. ...
Contrary to the statement on the National Autism Association's website, Dr. Hornig has not created a mouse model for autism. Not even close. So what is she "expanding"? She chronically overdosed autoimmune-disease-prone mice with mercury and didn't get autistic symptoms out of them, even though she was watching for what she assumed were the mousey version of autism symptoms. She chronically overdosed her mice with thimerosal in a manner that does not mimic the vaccine exposure infants received during the 1990's in the U.S., and got almost no behavioral change out of them, but she did get what looks like peripheral neuropathy which she didn't report in the original paper. Since all this mercury didn't seem to affect the non-immune-sensitive mice at all, how dangerous can mercury be? She doesn't report if the other mice had peripheral nerve damage symptoms maybe all the mice she injected with mercury started to chew on their feet because of the peripheral nerve damage.
But now, she will put mercury in her mice again and then, later inject gold into them. Presumably, she will inject the gold, since that was the treatment Donald T got. But, maybe she'll mix up a "transdermal" gold-salt cream. The gold is supposed to act like a chelator, even though there's no biochemical reason to think that it would act that way in the human or mouse body.
Gold salts are used in some forms of juvenile arthritis. The way the treatment is carried out is to give injections once a week until the gold builds up in the body to a sufficient level.
This would tend to imply that the gold goes in and stays in wouldn't it? If it's going in and staying in, is it also carrying mercury out of the body with it? Has Hornig looked into how much of the gold will stay in the mouse? Has she looked into the damaging effects of gold?
Here is some information on the use of gold salts in Juvenile Rheumatoid Arthritis:
Intramuscular gold salts
Gold salts have not been shown in studies to be effective in treating [Juvenile Rheumatoid Arthritis] JRA. However, some children have been observed to have long periods of remission when treated with gold salt injections.
Gold shots are not recommended for children with systemic JRA because of the possibility of severe side effects. Intramuscular gold salts are associated with more serious toxic reactions in children with systemic-onset JRA than in children with other types of JRA.
Side Effects
Side effects may develop after a significant amount of gold has built up in the body. Side effects from intramuscular gold salt therapy fall into three categories:
Common but less serious side effects include mouth sores, skin rashes, and hair thinning.
Less common but serious side effects include inflammation of the kidneys and reduced white blood cell, red blood cell, or platelet counts. These side effects can be detected early with regular blood and urine tests; if the drug is stopped, there is no permanent damage.
Rare and serious side effects include inflammation of the colon (colitis) and inflammation or scarring of the lung (pneumonitis).
More on side effects of gold salts from a different source:
Side Effects of This Medicine
Gold compounds have been shown to cause tumors and cancer of the kidney when given to animals in large amounts for a long time. However, these effects have not been reported in humans receiving gold compounds for arthritis. ...
Check with your doctor as soon as possible if any of the following side effects occur:
More common
Irritation or soreness of tongue-less common with auranofin; metallic taste-less common with auranofin; skin rash or itching; redness, soreness, swelling, or bleeding of gums-rare with auranofin; ulcers, sores, or white spots on lips or in mouth or throat
Less common
Bloody or cloudy urine; hives
Rare
Abdominal or stomach pain, cramping, or burning (severe); bloody or black, tarry stools;
confusion; convulsions (seizures); coughing, hoarseness, difficulty in breathing, shortness of breath, tightness in chest, or wheezing;
dark urine; decreased urination; decreased vision;
difficulty in swallowing; feeling of something in the eye;
fever; hair loss;
hallucinations (hearing, seeing, or feeling things that are not there);
irritation of nose, throat, or upper chest area, possibly with hoarseness or coughing; irritation of vagina; nausea, vomiting, or heartburn (severe and/or continuing);
numbness, tingling, pain, or weakness, especially in the face, hands, arms, or feet; pale stools;
painful or difficult urination; pain in lower back, side, or lower abdomen (stomach) area; pain, redness, itching, or tearing of eyes; pinpoint red spots on skin;
problems with muscle coordination; red, thickened, or scaly skin;
sore throat and fever with or without chills; swelling of face, fingers, ankles, lower legs, or feet; swellings (large) on face, eyelids, mouth, lips, and/or tongue;
swollen and/or painful glands; unusual bleeding or bruising; unusual tiredness or weakness;
vomiting of blood or material that looks like coffee grounds; yellow eyes or skin

Abstract describing how gold from sodium aurothio[1,4-14C]malate (Radioactive Carbon 14 tagged gold salts, apparently) is deposited in a rat's body, " Gold was located principally in kidney, liver, lung and spleen with smaller amounts elsewhere" So did the gold not get past the blood-brain-barrier? If so, is that a problem if you are trying to chelate mercury out of a kid's brain?
MYOCHRYSINE®, injectible sodium aurothiomalate, is made by Rhône-Poulenc Rorer. One of the first questions Hornig needs to ask is, "Is this stuff I intend to use made by the utterly evil BIG pharma. And, "If so, should I really be buying the stuff and thereby promoting the continuation of evil? " Someone needs to ask these tough questions. Maybe the Institutional Review Board at Columbia University will. But then, they are probably supported in part by the utterly evil BIG pharma.
The idea that gold salts turned Donald T from an autistic person into a normal person is just bizarre, but it's typical of the cargo cult thinking of the never-ending Dan Olmsted and his followers.
Autism Diva
Au/relia






19 Comments:
Hi AD -
This really takes the cake. I find it incredibly sad that parents will now feel they must jump through this hoop to grab the gold ring in order to "fix" their kids. I read recently one parent's email asking people why his kid's stools would be pale white, and everyone was asking him "are you chelating?" like it was the most natural thing in the world. I was in a sweat. If my kid started crapping white, we'd be in the emergency room in two seconds flat.
Among the younger, newly-diagnosed parents, here has been such a serious trend away from people following sound medical advice and people just going with what sounds like science, experimenting with their kids' lives. When I read the ridiculous advice out there, I feel like Charlie Brown listening with a stomach ache to Lucy explain to Linus that the rain actually falls up.
The truly strange part about this whole thing is the way a little crumb of anecdotal evidence has been magically transformed to fit the mercury hypothesis.
A chemistry professor, that is a qualified chemistry professor, should know the bond between mercury and gold, in their respective metallic states, is not a covalent, ionic, or even an intermetallic bond. It's more akin to an alloy. Assuming there isn't a whole lot of Hg(0)in a human body, and recognizing that gold salts are, and remain, Au(I) compounds in vivo, the two are very unlikely to be "attracted" at all.
SJL/J mice are not going to react well to injections of any heavy metal compounds and the quantities of gold used to treat RA are thousands of times higher than thimerosal in vaccines. Should we assume the mice will receive the same dose that Donald received? I only hope Horniq is honest enough to report the results even if she ends up killing the mice.
A little lesson on various kinds of chemical bonds.
Hi Susan Senator,
You can go on to the "autism-mercury" Yahoo! group and see parents passing around scary advice, new stuff every day. But you'd get a stomach ache.
:-(
It is really awful. Once the parents get into this mind set, they become "good parents" if they ignore mainstream doctors and mainstream science, so sometimes they don't take their kids to mainstream doctors when they need to.
http://onibasu.com/archives/am/159626.html
http://onibasu.com/archives/am/154578.html
For one thing, they know that what they are doing is "quirky" if not "quacky" outright, so they don't want to tell the doctor what they are doing...
been there done that,
probably not a good idea.
Please excuse the off-topic comment, but I don't know any other way to contact you.
I just found your blog through the link on Neurodiversity.com, and I'd like to exchange links with you (I link to your blog, you link to mine) if you'd be into it.
My blog is at http://www.nickykaa.com/journal/. It's not primarily a blog about autism, it's just the personal journal of one autistic person (i.e., me) who's leading a happy and interesting life partly as a result of having learned how to work with my own natural style and strengths instead of trying to be "less autistic."
Regards,
Nicky
Hi nicky,
Autism Diva glanced through your blog and web pages and thinks that you look like a fine fellow.
Autism Diva tries not to link to any site or blog that regularly includes stuff that is not good for children or old people (like Autism Diva) to see.
There's an activist blog that has some really interesting stuff, but it's called, "Autistic B**ch from H*ll" and uses some pretty strong language, as you can guess, so Autism Diva doesn't link to it.
Autism Diva doesn't have to agree with everything that people say on their blogs, though, in order to link to them.
Watch for your link in the "inside aut" section here.
:-)
I recommend they try fulminating gold. Only after testing it on themselves first, of course, just kidding no offense etc.
Hey! Fluorescent lights have mercury vapor in them! Fluorescent lights annoy auties! (and everyone else) Do ya think there might be a connection! (Just Kidding, again, ok?)
Recently there have been some discussions on at least one mercury-parent bulletin boards. Someone said that computer monitors had lead and mercury in them!!!
Autism Diva had an instantaneous vision of all the mercury parents leaving the internet for good. (Autism Diva thinks in pictures.)
No such luck. For some reason sitting in front of a heated glass and plastic box of mercury and lead doesn't worry them enough to quit it.
Strange people.
Hi Autism Diva,
I searched for your email address on your blog but couldn't find it. I have a 4 1/2 year old son who was asked to participate in a research study on DMSA.
The study involves the use of Glutathione to "detox" his body on preparation for the DMSA. My son is taking extra Zinc as well to help prepare him for the DMSA. There are to be urine collections which will not be easy because he isn't potty trained yet. We had his blood drawn already and the results have come back and I have gotten the o.k. to start the Gluathione. I asked the Doctor and nurse to please tell me the results of his blood work and they would not. They said all of the results would be made available at the end of the study for me to see. I asked the nurse how do I even know if he has mercury in him if you won't share the info and she said they want the study to not be biased.
I only want to help my son the best I can. I do not know much about DMSA and would like some help. I want my son to be safe but my gut tells me something isn't quite right. So I have the DMSA I received by mail, there are 11 capsules and I just do not know if I should try this. I know I must sound completely stupid but as I said before I just want to help my son. The nurse who is helping with the study told me to buy Mothering Magazines current issue and in it are recovered Autistic children. Help! I am not sure what to do. Any advice would be so greatly appreciated!
Hi,
Your site always provides great background. I'm actually in the process of pulling down every article on mercury in mice (it seems it all started because they used it for radiography). If I'm going to comment usefully on this subject, and why the whole autism community is focused on this is beyond me when there are more important things going on like the Medicaid budget for Autistic Children being slashed.
Since this seems to be the string for blog...well, since this is a family site I will not use the common "w" word, I'll go ahead and do it too.
I just started a Scoop blog for ASD - Our Spectrum. I just kicked it off and there are probably still some bugs, but I would love to have any of you come and join (free obviously) and drive the site. If you haven't seen a scoop site before it's pretty cool - see DailyKos.com
kcsmom,
I am not Autism Diva, but I would like to comment on this too.
I will guess that this study is the one out of the University of Arizona?
The reason you are not being told the lab results are due to a technique called "blinding". It is a legitimate and important tool in conducting some forms of research.
However (frowns) this should have been explained to you very carefully before you signed your informed consent paper.
As for advise, remember, you can withdrawl without penalty (this is a universal thing) at any time duing the study.
If you feel that they were dishonest than you should contact their Institution Review Board (IRB)(contact the university they are from).
Before any of that, you should simply ask to talk to the principle researcher and share your concerns. S/he probably has a good answer to your concerns.
P.S. I can't help, but to add a post script; you shared your concerns with a nurse and she told you to read a magazine to see "cured" kids (yech).
Diva,
I also noticed that conversation about mercury in computer monitors on that list.
Do you know that game where someone quickly moves cups around and a tiny ball is in one of them, and you have to guess which one it is under?
This is kind of like that. Where's the mercury? Is it under this cup? No? Come on, you know its somewhere!
Hi Interverbal,
Thank you for your input, I greatly appreciate it!
Yes the study if coming from Arizona:)
Anyone (I understand KC did) can read more details about the chelation study in Arizona at autismstreet.blogspot.com. It's a skeptical, but objective view - much of the so-called facts directly from the researchers themselves (via an e-mail conversation with the lead investigator). Don't take my word for it - READ UP!
Thanks for great article AD. I apologize for promoting the facts about a separate article in your comments section, but felt it warranted since KCsMom and Interverbal brought up the subject.
Hi KC's mom,
Sorry to be so tardy in replying.
First of all, if you are talking about the study in Arizona out of the Southwest Naturopathic College (or whatever it's called) the one discussed in detail on autismstreet.blogspot.com by Dad of Cameron... the problem with the results from the lab is that they came (or most likely came) from a questionable source.
Doctor's Data lab is not to be trusted, in Autism Diva's opinion.
If your son has a doctor, you might be able to get him or her to order the mercury tests from a local lab, which, would be a good idea before you start in on the experiment, or if you are really worried about this.
Mail order labs have a hideous reputation, it's not that all of their tests are wrong, it's just that for various reasons they way the deliver the results to you can be misleading, and besides that the results can be just plain wrong.
It's usually cheaper to have a local lab do the tests anyway.
Dr. Laidler has a nice discussion about chelation with DMSA and DMPS on the neurodiversity.com blog. It's very calm and rational, and lines out what is relatively safe in relation to these two drugs and what is relatively dangerous and why it's probably a bad idea for autistic kids even if DMSA is relatively safe.
here
Dr. Laidler is a real MD and board certified as a aneshesiologist, last time Autism Diva checked. He's also the dad of two spectrum kids and has been very involved in alt med (DAN!) type stuff for autism.
Autism Diva is far, far, far from being an MD or even an nurse. So her advice is based on watching the quacks and their sneaky tricks, and developing a sense for who is lying and who is not.
If you want to include Autism Diva's opinion in making this decision, don't give it much weight. Autism Diva's opinion is that you should not continue in the study.
Dr. Laidler's opinion, as expressed in the piece on neurodiversity, you should give more weight.
Interverbal told you some important stuff about how you have the right to back out of an experiment AT ANY TIME! This is a universal human right.
You need to listen to a normal non-DAN! doctor, one who can touch your child and listen to his heart and look in his ears. They aren't perfect, some can be horrible, but the odds are much better that you'll get good advice. You need to get advice from someone who knows your child, at least a little bit, in the flesh.
Overall, it's very risky to take specific medical advice from people on the internet.
Interverbal,
That's a shell game.
Dad of Cameron, you are welcome to promote you blog here.
rpeterson,
Autism Diva did not know what a scoop blog was, but it' looks like lots of news. You can promote your blog here, too. :-)
(what's the "w" word?" she asks tentatively... "woo woo"?)
Hi Autism Diva,
Thank you so much for your reply, I feel so much better.
Your site is just wonderful and I knew that I would find truth if I asked your opinion.
My gut was telling me something wasn't quite right with the study, I guess it was that information was being kept from me regarding my sons mercury levels. I mean we had his blood drawn and waited for the results only to be told they couldn't give them to us- What if he had NO Mercury in him? What would happen if we started Chelating a child who had no Mercury in his body? I am thinking the DMSA may remove things his body needs to keep him alive. I am so glad I am not going to participate in this study. It is too risky.
Thanks again for your opinions Autism Diva, Interverbal and Dad of Cameron. I appreciate them so much!
Hi Diva,
No that word would be more akin to the life lived by the main character in the Townes Van Zandt song Tecumseh Valley.
As for the Scoop blog, it's user driven. If someone wants to start a discussion on fixations, repetitive behavior, medicaid benefits, thimersol, ABA, social services, lack of social services, latest MRI imaging results, or whatever, they can. The users drive the discussion and the content. Of course, that would require users ; )
As for now, I am very upset about the Medicaid cuts for handicapped children, so I've been writing about that. But, soon I'm going to review some suggestions for agression from the Parents Survival Guide.
kcsmom, it does not seem to fishy to me that the nurse would not reveal the results of your son's blood work to you; if I understand this aspect of research protocol correctly, participants are not supposed to have this kind of information while the study is in progress. What did seem fishy was that she directed you to articles in Mothering Magazine about "recovering" autistic children -- children who are presumably "recovering" by means of the sort of regimen being tested in the study! In fact, one article is entitled, The Promise of Chelation -- quite a leading title. In doing so, the nurse is setting you up to be persuaded that chelation might be the source of any positive development in your son's life during the course of the study -- that is, she was setting you up to be biased. You are probably familiar with the common instruction to jurors not to read articles that pertain to the case on which they're serving -- the same rule should apply to participants in scientific studies, especially when those studies include parents' subjective reports of behavioral changes in their children.
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