What killed Abubakar?
Negligence brought on by hysteria and disinformation.
But more specifically, Endrate, also known as disodium EDTA. It's a chelator and an anticoagulent.
It comes with this
Here is some key information regarding it's use:
More information about disodium EDTA
Yeah. Keep out of reach of ear/nose/throat doctors, too.
And keep out of the veins of children because this chelator can be a heart-stopper.
Edit: Orac writes about the puzzling comments of Dr. Mary Jean Brown, chief of the Lead Poisoning Prevention Branch, Centers for Disease Control and Prevention, who is quoted as saying that, in general, chelation is safe for children.
Autism Diva
what next
But more specifically, Endrate, also known as disodium EDTA. It's a chelator and an anticoagulent.
It comes with this
WARNING:
The use of this drug in any particular patient is recommended only when the severity of the clinical condition justifies the aggressive measures associated with this type of therapy.
Here is some key information regarding it's use:
Edetate disodium is classified as a clinical chelating agent for emergency lowering of serum calcium in hypercalcemia.
The solution contains no bacteriostat, antimicrobial agent or buffer (except for pH adjustment) and is intended only for use (after dilution) as a single dose infusion. When smaller doses are required, the unused portion should be discarded.
Edetate Disodium, USP is chemically designated disodium (ethylenedinitrilo) tetraacetate dihydrate, a white crystalline powder soluble in water. It is also described as the disodium salt of ethylenediaminetetraacetic acid (EDTA)
More information about disodium EDTA
What is edetate disodium?
EDETATE DISODIUM, EDTA (Chealamide®, Disotate®, Endrate®) treats a condition called hypercalcemia, in which there is too much calcium in the blood. Edetate disodium can also treat irregular heart beats caused by too much digitalis (digoxin or digitoxin). Generic edetate disodium injections are available.
...
How should I use this medicine?
Edetate disodium is for slow infusion into a vein. It is given by a health-care professional in a hospital or clinic setting.
...
What side effects may I notice from receiving edetate disodium?
Side effects that you should report to your prescriber or health care professional as soon as possible:
•back pain
•bloody or cloudy urine
•fever or chills
•increased thirst
•irregular heartbeat
•lightheadedness or fainting spells
•muscle rigidity (stiffness), muscle cramps or pain
•numbness or tingling in the hands or feet
•pain, burning, or swelling at the injection site
•pain or difficulty passing urine, urgent need to pass urine, especially at night
•seizures (convulsions)
•skin rash
•unusual tiredness or weakness
Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome):
•diarrhea
•headache
•loss of appetite
•nausea, vomiting
•stomach pain
What should I watch for while taking edetate disodium?
Your condition will be closely monitored while you receive edetate disodium.
Edetate disodium can cause postural hypotension. Remain in bed for a short time after receiving the infusion. Do not sit or stand up quickly, this reduces the chance of dizzy or fainting spells.
Edetate disodium contains large amounts of sodium and should be used with caution in patients on sodium-restricted diets.
Where can I keep my medicine?
Keep out of the reach of children.
...
Yeah. Keep out of reach of ear/nose/throat doctors, too.
And keep out of the veins of children because this chelator can be a heart-stopper.
Edit: Orac writes about the puzzling comments of Dr. Mary Jean Brown, chief of the Lead Poisoning Prevention Branch, Centers for Disease Control and Prevention, who is quoted as saying that, in general, chelation is safe for children.
Autism Diva
what next
posted by Autism Diva at 9:48 PM
8 Comments:
Yeah, but calcium disodium edta is gooood for kids:
Package Insert for Calcium Disodium Versenate
(edetate calcium disodium injection, USP)
WARNINGS:
Calcium Disodium Versenate is capable of producing toxic effects which can be fatal. Lead encephalopathy is relatively rare in adults, but occurs more often in pediatric patients in whom it may be incipient and thus overlooked.
The mortality rate in pediatric patients has been high.
Patients with lead encephalopathy and cerebral edema may experience a lethal increase in intracranial pressure following, intravenous infusion; the intramuscular route is preferred for these patients. In cases where the intravenous route is necessary, avoid rapid infusion. The dosage schedule should be followed and at no time should the recommended daily dose be exceeded.
DESCRIPTION:
Calcium Disodium Versenate (edetate calcium disodium injection, USP) is a sterile, injectable, chelating agent in con-centrated solution for intravenous infusion or intramuscular injection. Each 5 ml ampul contains 1000 mg of edetate calcium disodium (equivalent to 200 mg/ml) in water for injection.
Chemically, this product is called [[N,N'-1,2-ethanediyl-bis[ N-(carboxymethyl)-glycinato]](4-)-N, N',O,O',O N ,ON ']-,disodium,hydrate, (OC-6-21)- Calciate(2-).
CLINICAL PHARMACOLOGY:
The pharmacologic effects of edetate calcium disodium are due to the formation of chelates with divalent and trivalent metals. A stable chelate will form with any metal that has the ability to displace calcium from the molecule, a feature shared by lead, zinc, cadmium, manganese, iron and mercury. The amounts of manganese and iron mobilized are not significant. Copper1 is not mobilized and
mercury is unavailable for chelation because it is too tightly bound to body ligands or it is stored in inaccessible body compartments.
The excretion of calcium by the body is not increased following intravenous administration of edetate calcium disodium, but the excretion of zinc is considerably increased [1].Edetate calcium disodium is poorly absorbed from the gastrointestinal tract. In blood, all the drug is found in the plasma. Edetate calcium disodium does not appear to penetrate cells; it is distributed primarily in the extracellular fluid with only about 5% of the plasma concentration found in spinal fluid.
The half life of edetate calcium disodium is 20 to 60 minutes. It is excreted primarily by the kidney, with about 50% excreted in one hour and over 95% within 24 hours [2]. Almost none of the compound is metabolized. The primary source of lead chelated by Calcium Disodium Versenate is from bone; subsequently, soft-tissue lead is redistributed to bone when chelation is stopped [3,4].
There is also some reduction in kidney lead levels following chelation therapy. It has been shown in animals that following a single dose of Calcium Disodium Versenate
urinary lead output increases,
blood lead concentration decreases,
but brain lead is significantly increased
due to internal redistribution of lead [5]. (See WARNINGS.)
These data are in agreement with the recent results of others in experimental animals showing that after a five day course of treatment there is no net reduction in brain lead [6].
INDICATIONS AND USAGE:
Edetate calcium disodium is indicated for the reduction of blood levels and depot stores of lead in lead poisoning (acute and chronic) and lead encephalopathy, in both pediatric populations and adults. Chelation therapy should not replace effective measures to eliminate or reduce further exposure to lead.
CONTRAINDICATIONS:
Edetate calcium disodium should not be given during periods of anuria, nor to patients with active renal disease or hepatitis.
WARNINGS:
See boxed warning.
PRECAUTIONS:
General Precautions: Edetate calcium disodium may produce the same renal damage as lead poisoning, such as proteinuria and microscopic hematuria. Treatment-induced nephrotoxicity is dose-dependent and may be reduced by assuring adequate diuresis before therapy begins. Urine flow must be monitored throughout therapy which must be stopped if anuria or severe oliguria develop. The proximal tubule hydropic degeneration usually recovers upon cessation of therapy. Edetate calcium disodium must be used in reduced doses in patients with pre-existing mild renal disease. Patients should be monitored for cardiac rhythm irregularities and other ECG changes during intravenous therapy.
Information for patients: Patients should be instructed to immediately inform their physician if urine output stops for a period of 12 hours.
Laboratory tests: Urinalysis and urine sediment, renal and hepatic function and serum electrolyte levels should be checked before each course of therapy and then be monitored daily during therapy in severe cases, and in less serious cases after the second and fifth day of therapy. Therapy must be discontinued at the first sign of renal toxicity. The presence of large renal epithelial cells or increasing number of red blood cells in urinary sediment or greater proteinuria call for immediate stopping of edetate calcium disodium administration. Alkaline phosphatase values are frequently depressed (possibly due to decreased serum zinc levels), but return to normal within 48 hours after cessation of therapy. Elevated erythrocyte protoporphyrin levels (>35 mcg/dl of whole blood) indicate the need to perform a venous blood lead determination. If the whole blood lead concentration is between 25-55 mcg/dl a mobilization test can be considered.7,8 (See Diagnostic Test.) An elevation of urinary coproporphyrin (adults: >250 mcg/day; pediatric patients under 80 lbs: >75 mcg/day) and elevation of urinary delta aminolevulinic acid (ALA) (adults: >4 mg/day; pediatric patients: >3 mg/ m 2 /day) are associated with blood lead levels >40 mcg/dl. Urinary coproporphyrin may be falsely negative in terminal patients and in severely iron-depleted pediatric patients who are not regenerating heme.9 In growing pediatric patients long bone x-rays showing lead lines and abdominal x-rays showing radioopaque material in the abdomen may be of help in estimating the level of exposure to lead.
Drug Interactions: There is no known drug interference with standard clinical laboratory tests. Steroids enhance the renal toxicity of edetate calcium disodium in animals.7 Edetate calcium disodium interferes with the action of zinc insulin preparations by chelating the zinc.7 Carcinogenesis, Mutagenesis, Impairment of Fertility: Long term animal studies have not been conducted with edetate calcium disodium to evaluate its carcinogenic potential, mutagenic potential or its effect on fertility.
(from chelationwatch.org)
Hi Diva, this is certainly worth repeating:
"mercury is unavailable for chelation because it is too tightly bound to body ligands or it is stored in inaccessible body compartments."
If mercury from shots is able to be chelated then it should be (at least somewhat) free in solution (blood). If that were the case then any lab from any sizeable hospital ought to be able to pick that up.
The EDTA isn't going to strip off the mercury from some binding site by accelerating the dissociation of Hg. The only way it could work is by lurking near the Hg complex, happening upon a dissociated Hg atom and binding it. This would be the case if there was some mercury in the blood.
To complicate matters the EDTA has to be unbound itself. In other words, if there's a calcium atom bound then EDTA isn't hungry and it keeps on going by. The calcium must dissociate leaving a free EDTA to happen upon the free Hg.
It's like love.
What killed Abubakar? Plain and simple, he was in America to cure his autism. What killed him was the belief that autism is such a devastating disease that it justifies any attempt to cure it; no matter how risky or controversial the treatment.
Abubakar died because people lied to his parents about autism and they believed those lies.
Autism Diva is thinking about that Sesame Street classic, "you got to put down the ducky if you want to play the saxophone"... this will be entirely obvious to sophisticated watchers of Sesame Street where we learned about logic and things like you can't always have things both ways.
Thank you Mike Stanton. Autism Diva hopes no more parents are lured to the U.S. for "autism therapy."
autism diva said: this will be entirely obvious to sophisticated watchers of Sesame Street where we learned about logic and things like you can't always have things both ways.
It is possible to play the sax with a rubber ducky in one hand. I don't know if it's possible to blow your own horn with both hands inside a puppet while the puppet holds a bird, but neither will make you Charlie Parker.
Hey speaking of sax and violins, when's the next Power of Truth Honker Ducky Dinger Jamboree?
Autism Diva has wondered the same thing. Where are the plans for the next Power to the Parents Honkie Dorky Dingbat Jamboree? No, Autism Diva got the spelling wrong there.
Power to the Peasants Hunkee Dooree Dunger Jamboree?
Autism Diva hears that they are planning on showing up with pitchforks and flaming torches... or something... getting the permits has been a big headache.
Clone, you've got to leave that ducky alone.
Post a Comment
Links to this post:
Create a Link
<< Home